Anti-EDD1

Anti-EDD1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A303-045A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A303-045A 100 µl (100 µg) -

2 - 8 Werktage*

588,00 €
 
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.... mehr
Produktinformationen "Anti-EDD1"
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. [The UniProt Consortium]
Schlagworte: Anti-EDD, Anti-UBR5, Anti-hHYD, EC=2.3.2.26, Anti-Progestin-induced protein, Anti-E3 ubiquitin-protein ligase UBR5, Anti-Hyperplastic discs protein homolog, Anti-HECT-type E3 ubiquitin transferase UBR5, Anti-E3 ubiquitin-protein ligase
Hersteller: Bethyl Laboratories
Hersteller-Nr: A303-045A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse (Erwartet: rat)
Immunogen: synthetic peptide. The epitope recognized by A303-045A-T maps to a region between residue 2749 and 2799 of human E3 Ubiquitin Protein Ligase, HECT domain using the numbering given in entry NP_056986.2 (GeneID 51366).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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