Anti-DAF

Anti-DAF antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. DAF antibody is human specific. At least two isoforms of DAF are known to exist, this antibody will only detect the longest isoform. Protein function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. [The UniProt Consortium]