Anti-Cyclin A, clone E67

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdkÆs) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdkÆs. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase. Protein function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. [The UniProt Consortium]