Anti-CUL5

CUL5 (Cullin 5) is a Protein Coding gene. Among its related pathways areInnate Immune SystemandCDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene includeprotein heterodimerization activityandubiquitin protein ligase binding. An important paralog of this gene isCUL1. Protein function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5- SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. [The UniProt Consortium]