Anti-CPNE1

Polyclonal Antibody against Human CPNE1, Gene description: copine 1, Alternative Gene Names: CPN1, Validated applications: ICC, Uniprot ID: Q99829, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium- dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation, induces neurite outgrowth via a AKT-dependent signaling cascade and calcium- independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). [The UniProt Consortium] Mouse gene identity: 87% Rat gene identity: 87%