Anti-Clostridium Difficile Toxin B

Clostridium difficile is a gram­positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin B (TcdB) is a large exotoxin. Its role in disease is less well understood than that of toxin A, though it seems clear that TcdB contributes to disease. Both toxins modifies the Ras superfamily of small GTPases via glycosylation, inactivating them and leading to the disruption of vital signaling pathways in the cell. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:20-1:200, Optimal dilutions to be determined by the researcher. Recommended Secondary Antibodies: I1904-25D IgG, H&L (AP) Pab Gt xMo, I1904-67AA IgG, H&L (AP) Pab Gt xMo, I1904-65N IgG (HRP) Pab Rb xMo, I1903-07E IgG (HRP) Pab Rb xMo, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.