Anti-CLDN2

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. Protein function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. [The UniProt Consortium]