Anti-Citrullinated LL-37 (Clone 6A8)

LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and a variety of immune cells. It has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities. Citrullinated, unlike native, LL-37 does not prevent mortality in a mouse model of D-galactosamine-sensitized endotoxic shock. Citrullinated LL-37 has been found in neutrophil extracellular traps (NETs), as well as the serum of patients with rheumatoid arthritis (RA) and individuals without RA. Cayman's Citrullinated LL-37 Monoclonal Antibody (Clone 6A8) can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated LL-37 at approximately 9 kDa from human samples.Synonyms: Antibacterial Peptide LL-37, Antibacterial Protein LL-37. Immunogen: Citrullinated human LL-37 peptide. Clone Designation: 6A8. MW: ~9 kDa. Formulation: (Request formulation change), 300 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, WB. Cross Reactivity: (+) Citrullinated LL-37, (-) Native LL-37. UniProt Accession #: P49913.