Anti-CENP-E

Anti-CENP-E
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-942A-T 10 µl (10 µg) -

3 - 9 Werktage

125,00 €
A301-942A 100 µl (100 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Microtubule plus-end-directed kinetochore motor which plays an important role... mehr
Produktinformationen "Anti-CENP-E"
Protein function: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule- kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips, after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. [The UniProt Consortium]
Schlagworte: Anti-CENPE, Anti-CENP-E, Anti-Kinesin-7, Anti-Centromere protein E, Anti-Kinesin-related protein CENPE, Anti-Centromere-associated protein E
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-942A-T

Eigenschaften

Anwendung: IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by A301-942A-T maps to a region between residue 2050 and 2100 of human centromere protein E using the numbering given in entry NP_001804.2 (GeneID 1062).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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