Anti-CEA, clone YN00176m

CEA is a kind of embryonic cancer antigen, which normally express in fetal digestive tract epithelium, pancreas and liver. CEA antibodies can be used to classify the adenocarcinoma, especially in the gastrointestinal tract, including colon and pancreatic cancers. CEA also helps to distinguish secretory meningioma from medullary thyroid cancer. Protein function: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression, induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). [The UniProt Consortium]