Anti-CDK5RAP1

Polyclonal Antibody against Human CDK5RAP1, Gene description: CDK5 regulatory subunit associated protein 1, Alternative Gene Names: C20orf34, C42, CGI-05, HSPC167, Validated applications: ICC, Uniprot ID: Q96SZ6, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain, shows pathological consequences in mitochondrial disease (PubMed:25738458). [The UniProt Consortium] Mouse gene identity: 70% Rat gene identity: 70%