Anti-CDC40, clone IAO-3

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Pre-mRNA splicing occurs in two sequential transesterification steps. 'Pre-mRNA-processing factor 17,' also called EHB3, PRP17, PRPF17 and CDC40, is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [RefSeq] Protein function: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development, this function does not require proline isomerization (PubMed:33220177). [The UniProt Consortium]