Anti-CD86 Phycoerythrin Conjugated, clone IT2.2

Phycoerythrin conjugated CD86 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD86. Reactivity is observed against human CD86. Cross reactivity is observed with Baboon, Capuchin Monkey, Common Marmoset, Cotton-topped Tamarin, Chimpanzee, Cynomolgus, and Rhesus . Reactivity with CD86 from other sources has not been tested. Anti-CD86 is conjugated with PE under optimal conditions and the solution is free of unconjugated PE. Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [The UniProt Consortium]