Anti-CD86 (human), Unconjugated Clone B-T7 [Mouse]

Specificity: Recognises the B7.2, B70 antigen, a 80 kDa protein, Format: Phosphate-buffered saline with 1 % BSA and 0.09 % sodium azide, Working Dilution: Use 10 µl to label 106 cells or 100 µl of whole blood, Storage: Stable at +2-8°C for 12 months. For longer storage freeze aliquots, Application Notes: Suitable for Flow Cytometry Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. [The UniProt Consortium]