Anti-CD8 alpha Recombinant Monoclonal

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A700-044-T 10 µl (5+ tests) -

2 - 8 Werktage*

172,00 €
A700-044 100 µl (50+ tests) -

2 - 8 Werktage*

655,00 €
 
Protein function: Integral membrane glycoprotein that plays an essential role in the immune... mehr
Produktinformationen "Anti-CD8 alpha Recombinant Monoclonal"
Protein function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK- cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. [The UniProt Consortium]
Schlagworte: Anti-MAL, Anti-CD8a, Anti-CD8A, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2
Hersteller: Bethyl Laboratories
Hersteller-Nr: A700-044

Eigenschaften

Anwendung: WB, IHC, IHC-IF, FC, MIF
Antikörper-Typ: Monoclonal
Klon: BLR044F
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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