Anti-CD79, clone SPM549

Anti-CD79, clone SPM549
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V9109-20UG 20 µg - -

3 - 10 Werktage*

332,00 €
NSJ-V9109-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. A disulphide-linked heterodimer,... mehr
Produktinformationen "Anti-CD79, clone SPM549"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well. Protein function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. [The UniProt Consortium]
Schlagworte: Anti-IGA, Anti-CD79a, Anti-CD79A, Anti-Ig-alpha, Anti-MB-1 membrane glycoprotein, Anti-Surface IgM-associated protein, Anti-Membrane-bound immunoglobulin-associated protein, Anti-B-cell antigen receptor complex-associated protein alpha chain, CD79 Antibod
Hersteller: NSJ Bioreagents
Hersteller-Nr: V9109

Eigenschaften

Anwendung: FC, IF, IHC
Antikörper-Typ: Monoclonal
Klon: SPM549
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Amino acids 202-216 (GTYQDVGSLNIADVQ-human) from the alpha chain were used as the immunogen for this CD79 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-CD79, clone SPM549"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen