Anti-CD61 (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, ITGB3, GP3A)

CD61, known as integrin b3 or glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of integrin family that associates with platelet gpIIb (CD41) forming CD41/CD61 complex and associates with integrin aV (CD51) forming aV/b3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblast, macrophages and some tumor cells, involved in tumor metastasis and in adenovirus infection through binding to RGD motif ECM proteins. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.