Anti-CD6, clone SPV-L14

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular "scavenger receptor cysteine-rich" (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease. Protein function: Involved in cell adhesion. Binds to CD166. [The UniProt Consortium]