Anti-CD54

ICAM-1 (CD54) is a 90-kDa transmembrane glycoprotein of the immunoglobulin superfamily and is critical for the firm attachment and transmigration of leukocytes out of blood vessels and into tissues . ICAM-1 is expressed by several cell types,typically on endothelial cells and cells of the immune system,and its expression can be up-regulated by various stimuli,including TNF-a,INF-?,IL-1 and thrombin . It is a ligand for LFA-1 and Mac-1,serves as a receptor for rhinovirus,and is one of several receptors used by Plasmodium falciparum . Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. [The UniProt Consortium]