Anti-CD42b, gpIb, FITC conjugated, clone 3H1309

The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Symdrome (BSS). Antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation. Recommended Secondary Antibody: Recommended Negative Controls: Mouse IgG1 Negative Control: FITC, Applications: Flow Cytometry: 1:10, Optimal working dilutions to be determined by researcher. Flow Cytometry: Use 10ul of the suggested working dilution to label 100ul whole blood. , Storage and Stability:, Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. , Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.