Anti-CD34, clone YN00326m

CD34 is a single strand membrane penetrating protein with a molecular weight of 105~120 kDa, which is expressed in early LYMPHOPOIETIC stem cells, Progenitor cells, vascular endothelial cells, embryonic fibroblasts and some nerve tissue cells. It is mainly used for the differentiation of benign and malignant angiogenic tumors. CD34 and CD117 are used in the identity gastrointestinal stromal tumors. CD34 is positive in 80%~ 102% of dermatofibrosarcoma protuberans, which could be differentiated from dermatofibroma. Protein function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. [The UniProt Consortium]