Anti-CD34 (Clone ICO-115)

CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells. It is composed of an N-terminal signaling peptide, a sialylated and O-glycosylated extracellular mucin domain, a cysteine-containing globular domain, a juxtamembrane stalk region, and an intracellular C-terminal tail. CD34 is expressed primarily in hematopoietic progenitor cells but is also expressed in mesenchymal stromal, muscle satellite, interstitial, epithelial and vascular endothelial progenitor, and adipose mesenchymal stem/stromal cells. It has both pro- and anti-adhesion activities, providing an anchor for L-selectin-mediated attachment of lymphocytes in vascular endothelial cells and blocking adhesion of bone marrow-derived mast cells in vitro. CD34 has commonly been used as a marker for the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Cayman's CD34 Monoclonal Antibody (Clone ICO-115) can be used for flow cytometry (FC) and immunocytochemistry (ICC) applications.Synonyms: Hematoietic Progenitor Cell Antigen CD34. Clone Designation: ICO-115. Formulation: (Request formulation change), 100 µg purified IgG1 monoclonal antibody. Storage Buffer: 500 µl PBS, pH 7.2, with 0.02% sodium azide. Host: Mouse. Applications: FC, ICC. Cross Reactivity: (+) CD34. Origin: Animal/Mouse.