Anti-CD23 (human), Rabbit Monoclonal (RM406)

Recombinant Antibody. This antibody reacts to human to CD23. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD23 (Fc epsilon RII, FcepsilonRII) is a glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is a low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, found on B cells. It is expressed on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. Functionally, CD23 is involved in B cell growth and differentiation and IgE production. CD23 is known to have a role of transportation in antibody feedback regulation. CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.