Anti-CD146, clone RM249 (recombinant antibody)

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant CD146 antibody reacts to human CD146 (Cell surface glycoprotein MUC18). It may also react to the mouse and rat protein, as predicted by immunogen homology. Protein function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [The UniProt Consortium]