Anti-Caveolin-1

Anti-Caveolin 1 was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with lemur, sheep, bat, rat, rabbit, pig, and primate based on 100% sequence homology. Cross-reactivity with Caveolin 1 from other sources has not been determined. Caveolin 1 is a ubiquitous protein found within the membranes of caveolea, theoretically acting as a scaffolding protein. Direct interaction with G-protein alpha subunits allows regulation of their activity. A regulatory protein, it is involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, and is also a factor in the regulation of CTNNB1-mediated signaling through the Wnt pathway. Expressed in the muscle and lung tissues predominantly, defects in CAV1 is the cause of congenital generalized lipodystrophy type 3, or autosomal recessive disorders such as adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset diabetes. Anti-Caveolin 1 antibody is ideal for researchers in Metabolism, Cancer, Signal Transduction, and Cardiovascular research.