Anti-Caspase-9

Anti-Caspase-9 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. It has no cross response to other members in caspase family. Protein function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP). [The UniProt Consortium]