Anti-Calponin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM262)

Calponin-1 is an actin binding protein and a component of smooth muscle cell (SMC) contractile machinery that is encoded by CNN1 in humans. It is a thin filament-associated protein expressed exclusively in SMCs that interacts with actin to inhibit the movement of actin and myosin, as well as the actin-activated MgATPase activity of phosphorylated myosin. High levels and low levels of calponin-1 are associated with low and high disease progression risk, respectively, in patients with ductal carcinoma in situ (DCIS). Downregulation of arterial Cnn1 expression promotes proliferation of vascular SMCs (VSMCs) in DOCA-salt hypertensive rats and a pig model of hypertension induced by aortic coarctation. Cayman's Calponin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM262) can be used for immunocytochemistry (ICC) and Western blot (WB) applications.Synonyms: CaP. Immunogen: Peptide from the C-terminal region of human calponin-1. Clone Designation: RM262. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ICC, WB. Cross Reactivity: (+) Calponin-1.