Anti-CALD1 (human), Rabbit Monoclonal (RM396)

Recombinant Antibody. This antibody reacts to human CALD1 . Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CALD1 (Caldesmon) is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This calmodulin- and actin-binding protein plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin and phospholipids. It is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.