Anti-Cadherin-17 (human), Rabbit Monoclonal (RM529)

Cadherin-17 is a calcium-dependent cell adhesion molecule belonging to the cadherin superfamily. It is predominantly expressed in the epithelial cells of the gastrointestinal tract and liver, where it helps maintain cell-cell adhesion and epithelial integrity. Unlike classical cadherins, Cadherin-17 lacks a cytoplasmic catenin-binding domain, suggesting a specialized role in intestinal cell organization and signaling. Its overexpression has been observed in several gastrointestinal cancers, making it a useful diagnostic marker and potential therapeutic target.