Anti-CACNG3

calcium voltage-gated channel auxiliary subunit gamma 3(CACNG3) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010], Protein function: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. [The UniProt Consortium] Recommended dilutions: WB: 1:1000-2000 IHC: 1:200-500. Cellular localization: Membrane , Multi-pass membrane protein . Displays a somatodendritic localization and is excluded from axons in neurons. .