Anti-c-Myc, clone 90000000000

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.. c-Myc Antibody targets c-Myc, also known as MYC, a nuclear transcription factor encoded by the MYC gene that functions as a central regulator of cellular growth, metabolism, and proliferation. c-Myc is a member of the Myc family of basic helix-loop-helix leucine zipper proteins and is widely recognized for its ability to coordinate large-scale gene expression programs. Through this regulatory capacity, c-Myc integrates extracellular growth signals with intracellular metabolic and biosynthetic demands.Functionally, c-Myc exerts its effects on gene expression by forming heterodimers with the MAX protein. The c-Myc-MAX complex binds to specific DNA motifs within promoters and enhancers of target genes, influencing transcriptional output across diverse biological pathways. These targets include genes involved in ribosome biogenesis, nucleotide synthesis, mitochondrial activity, and cell cycle progression. A c-Myc Antibody enables investigation of MYC-driven transcriptional regulation and growth-associated gene networks in research studies.Expression of c-Myc is tightly regulated and highly responsive to mitogenic stimuli. In quiescent cells, MYC expression is generally low, while growth factor signaling induces rapid transcriptional activation and protein accumulation. At the subcellular level, c-Myc localizes predominantly to the nucleus, where it associates with chromatin and transcriptional machinery. Its short protein half-life allows cells to fine-tune MYC activity in response to changing environmental and metabolic conditions.At the molecular level, c-Myc contains a conserved C-terminal DNA-binding and dimerization domain responsible for interaction with MAX, along with N-terminal regulatory regions that modulate transcriptional activation and protein stability. These regulatory regions interact with cofactors and chromatin-associated proteins, enabling c-Myc to influence both gene activation and repression depending on cellular context. Post-translational modifications further regulate MYC stability and activity, contributing to precise control of its biological effects.From a biological and disease relevance perspective, dysregulation of MYC is a hallmark of many cancers. Sustained MYC activation can drive uncontrolled cell proliferation, metabolic reprogramming, and altered differentiation states. Amplification, overexpression, or deregulated signaling upstream of MYC has been observed across a wide range of tumor types, making c-Myc a focal point of cancer biology research. As a result, MYC expression is frequently examined as an indicator of proliferative signaling and oncogenic transcriptional activity.c-Myc Antibody reagents are valuable tools for studying transcription factor biology, growth control mechanisms, and MYC-associated signaling pathways. These antibodies support research into gene expression regulation, cellular metabolism, and disease-associated alterations in transcriptional programs. NSJ Bioreagents provides c-Myc Antibody products intended for research use.