Anti-BRCA2 (352-643)

Anti-BRCA2 (352-643)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NB-26364-1 100 µl - -

3 - 16 Werktage*

346,00 €
 
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50%... mehr
Produktinformationen "Anti-BRCA2 (352-643)"
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Protein function: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SHFM1/DSS1, and is required to prevent R-loop- associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). [The UniProt Consortium]
Schlagworte: Anti-FACD, Anti-BRCA2, Anti-Fanconi anemia group D1 protein, Anti-Breast cancer type 2 susceptibility protein
Hersteller: NewEast Biosciences
Hersteller-Nr: 26364-1

Eigenschaften

Anwendung: ELISA, WB, IHC
Antikörper-Typ: Monoclonal
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: vertebrates
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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