Anti-BCL-6, clone SP155

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG52561.100 100 µl - -

6 - 14 Werktage*

608,00 €
 
Protein function: Transcriptional repressor mainly required for germinal center (GC) formation... mehr
Produktinformationen "Anti-BCL-6, clone SP155"
Protein function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53- dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH- dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. [The UniProt Consortium]
Schlagworte: Anti-BCL6, Anti-BCL5, Anti-BCL-6, Anti-BCL-5, Anti-Protein LAZ-3, Anti-Zinc finger protein 51, Anti-B-cell lymphoma 6 protein, Anti-B-cell lymphoma 5 protein, Anti-Zinc finger and BTB domain-containing protein 27
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG52561

Eigenschaften

Anwendung: IHC (paraffin), FC
Antikörper-Typ: Monoclonal
Klon: SP155
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: rat)
Immunogen: Synthetic peptide derived from the C-terminus of human BCL-6 protein
Format: Liquid

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
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Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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