Anti-BARD1 (BRCA1 Associated Ring Domain 1)

Anti-BARD1 (BRCA1 Associated Ring Domain 1)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
B0085-01C.50 50 µg - -

3 - 19 Werktage*

531,00 €
 
BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in... mehr
Produktinformationen "Anti-BARD1 (BRCA1 Associated Ring Domain 1)"
BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal ring motif and the C-terminal BRCT domain. The ring motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interation is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. Applications: Suitable for use in Dot Blot, Western Blot and Immunoprecipitation. Other applications have not been tested. Recommended Dilution: Western Blot: 0.2-2ug/ml. , Immunoprecipitation: 100-500ug/sample, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: EC=6.3.2.-, Anti-BARD-1, Anti-BRCA1-associated RING domain protein 1
Hersteller: United States Biological
Hersteller-Nr: B0085-01C

Eigenschaften

Anwendung: Dot Blot, IP, WB
Antikörper-Typ: Monoclonal
Klon: 8C29
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant hum
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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