Anti-Aven, CT

Anti-Aven, CT
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A4445-11M.100 100 µg - -

3 - 19 Werktage*

644,00 €
 
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of... mehr
Produktinformationen "Anti-Aven, CT"
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a vari ety of diseases such as cancer (reviewed in 1). Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9 (2). It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients (3). Despite its predicted molecular weight, Aven often migrates at 55kD in SDS-PAGE. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml. See A4445-10A for control peptide., Immunohistochemistry: 5ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Raji cell lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: Anti-Cell death regulator Aven
Hersteller: United States Biological
Hersteller-Nr: A4445-11M

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: 14 amino acid peptide from near the carboxy terminus of human Aven (GenBank accession no. NP_065104)
Format: Affinity Purified

Datenbank Information

UniProt ID : Q9NQS1 | Passende Produkte
Gene ID GeneID 57099 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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