Anti-ATG5

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-14583.20 20 µl -

7 - 16 Werktage*

71,00 €
E-AB-14583.60 60 µl -

7 - 16 Werktage*

143,00 €
E-AB-14583.120 120 µl -

7 - 16 Werktage*

238,00 €
E-AB-14583.200 200 µl -

7 - 16 Werktage*

396,00 €
 
Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene. It is an E3... mehr
Produktinformationen "Anti-ATG5"
Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene. It is an E3 ubiquitinligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II. Protein function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. [The UniProt Consortium]
Schlagworte: Anti-ATG5, Anti-APG5L, Anti-APG5-like, Anti-Autophagy protein 5, Anti-Apoptosis-specific protein, ATG5 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-14583

Eigenschaften

Anwendung: IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human ATG5
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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