Anti-ATG12

Anti-ATG12
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F46258-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F46258-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Macroautophagy is the major inducible pathway for the... mehr
Produktinformationen "Anti-ATG12"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L/ATG12 is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy. Protein function: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. [The UniProt Consortium]
Schlagworte: Anti-ATG12, Anti-APG12, Anti-APG12-like, Anti-Autophagy-related protein 12, Anti-Ubiquitin-like protein ATG12, ATG12 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F46258

Eigenschaften

Anwendung: IF, WB, IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this ATG12 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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