Protein function: Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis. [The UniProt Consortium]
Anti-DEF-1, Anti-ASAP1, Anti-DDEF1, Anti-PIP2-dependent ARF1 GAP, Anti-ARF GTPase-activating protein 1, Anti-Differentiation-enhancing factor 1, Anti-Development and differentiation-enhancing factor 1
synthetic peptide. The epitope recognized by A302-118A-T maps to a region between residue 750 and 800 of human ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 using the numbering given in entry NP_060952.2 (GeneID 50807).