Protein function: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. [The UniProt Consortium]
Anti-ARFGAP1, Anti-ARF1GAP, Anti-ARF1 GAP, Anti-ARF GAP 1, Anti-ARF1-directed GTPase-activating protein, Anti-ADP-ribosylation factor 1 GTPase-activating protein, Anti-ADP-ribosylation factor GTPase-activating protein 1
synthetic peptide. The epitope recognized by A302-029A-T maps to a region between residue 356 and 406 of human ADP-ribosylation factor GTPase activating protein 1 using the numbering given in entry NP_060679.1 (GeneID 55738).