Anti-AN13B

Protein function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cell membrane . Late endosome . Early endosome . Interaction with EGFR may enhance association with the cell membrane.