Anti-ACOD1

Polyclonal Antibody against Human ACOD1, Gene description: aconitate decarboxylase 1, Alternative Gene Names: CAD, IRG1, Validated applications: ICC, Uniprot ID: A6NK06, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS- tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells, ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages (PubMed:23610393). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation. [The UniProt Consortium] Mouse gene identity: 86% Rat gene identity: 86%