Zu "K16653" wurden 6 Artikel gefunden!
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DprE1-IN-2
Artikelnummer: TGM-T4044-10mg
Description: DprE1-IN-2 is an effective DprE1 inhibitor. Target: Antibacterial, DprE1. Smiles: CN(C)c1ncnc(Cn2cc(C(=O)NCCO)c3ncc(C)cc23)c1C. References: Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10,57(13):5728-37.
| Anwendung: | DprE1 inhibitor |
| CAS | 1615713-87-5 |
| MW: | 368.43 D |
ab 42,00 €
Macozinone
Artikelnummer: TGM-T3583-100mg
Description: Macozinone (PBTZ169) inhibits decaprenylphosphoryl-beta-d-ribose 2'-oxidase (DprE1), more efficiently than BTZ043. Target: DprE1, Antibacterial. Smiles: [O-][N+](=O)c1cc(cc2c1sc(nc2=O)N1CCN(CC2CCCCC2)CC1)C(F)(F)F. References: González-Martínez NA,et al. In Vivo Activity of the Benzothiazinones PBTZ169...
| Schlagworte: | PBTZ169 |
| Anwendung: | DprE1 inhibitor |
| CAS | 1377239-83-2 |
| MW: | 456.48 D |
ab 31,00 €
AZ 7371
Artikelnummer: Cay19310-1
AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1, IC50 = 10 nM), an enzyme involved in mycobacterial cell wall biogenesis. It inhibits wild-type M. smegmatis DprE1 and DprE1 harboring the drug-resistance mutation C394G (IC50 = 0.01 µM for both) but not the Y321H mutation...
| Schlagworte: | N-(2-hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide |
| Anwendung: | DprE1 inhibitor |
| CAS | 1494675-86-3 |
| MW: | 355.4 D |
ab 61,00 €
DprE1-IN-2
Artikelnummer: Cay21034-1
DprE1-IN-2 is an antitubercular agent that is active against M. tuberculosis in vitro, with MIC values ranging from 0.5 to 1.56 µM. It is an inhibitor of decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1, IC50 = 32 nM), an enzyme involved in mycobacterial cell wall biogenesis. DrpE1-IN-2 (300 mg/kg) reduces...
| Schlagworte: | 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide |
| Anwendung: | DprE1 inhibitor |
| CAS | 1615713-87-5 |
| MW: | 368.4 D |
ab 52,00 €
PBTZ169
Artikelnummer: Cay22202-1
PBTZ169 is an antibiotic with antimycobacterial activity. It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria. PBTZ169 is active against M. tuberculosis in vitro (MIC = =0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 µM....
| Schlagworte: | 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| Anwendung: | DprE1 inhibitor |
| CAS | 1377239-83-2 |
| MW: | 456.5 D |
ab 44,00 €
BTZ043
Artikelnummer: Cay22930-1
BTZ043 is an antibiotic with antimycobacterial activity. It targets mycobacterial cell wall synthesis by inhibiting DprE1, which, in conjunction with DprE2, catalyzes the epimerization of decaprenylphosphoryl ribose to decaprenylphosphoryl arabinose. BTZ043 is active against various Mycobacterium species in vitro,...
| Schlagworte: | 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| Anwendung: | DprE1 inhibitor, antimycobacterial |
| CAS | 1161233-85-7 |
| MW: | 431.4 D |
ab 52,00 €