Zu "K13241" wurden 138 Artikel gefunden!
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L-NIL (hydrochloride)
Artikelnummer: Cay80310-10
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
| Schlagworte: | N6-(1-iminoethyl)-L-lysine, dihydrochloride |
| Anwendung: | iNOS inhibitor |
| CAS | 159190-45-1 |
| MW: | 260.2 D |
ab 83,00 €
Anti-Recombinant iNOS, clone A267
Artikelnummer: E-AN301568L.100
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9...
| Schlagworte: | Anti-Nos2, Anti-NOS type II, Anti-Macrophage NOS, Anti-Inducible NO synthase, Anti-Nitric oxide synthase, inducible,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 304,00 €
Anti-NOS2 / iNOS
Artikelnummer: NSJ-F54232-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination...
| Schlagworte: | Anti-NOS2, Anti-NOS type II, Anti-Hepatocyte NOS, Anti-Inducible NO synthase, Anti-Nitric oxide synthase, inducible,... |
| Anwendung: | WB, IHC (paraffin), FC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
Diphenyleneiodonium (chloride)
Artikelnummer: Cay81050-10
Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX, EC50 = 0.1 µM in HeLa cells). It also inhibits nitric oxide synthase (NOS, IC50 = 0.05 µM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 µM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical...
| Schlagworte: | DPI, dibenziodolium chloride |
| Anwendung: | iNOS inhibitor, eNOS inhibitor |
| CAS | 4673-26-1 |
| MW: | 314.5 D |
ab 68,00 €
AMT (hydrochloride)
Artikelnummer: Cay81010-10
AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations, the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.Formal Name: 5,6-dihydro-6-methyl-4H-1,3-thiazin-2-amine, hydrochloride. CAS...
| Schlagworte: | 5,6-dihydro-6-methyl-4H-1,3-thiazin-2-amine, hydrochloride |
| Anwendung: | iNOS inhibitor |
| CAS | 21463-31-0 |
| MW: | 166.7 D |
ab 93,00 €
Anti-iNOS
Artikelnummer: Cay160862-1
Nitric Oxide Synthase (NOS) catalyzes the biosynthesis of nitric oxide from L-arginine. Constitutively expressed NOS is found in brain (nNOS) and endothelial cells (eNOS). iNOS is a soluble enzyme found in a variety of tissues including macrophages, hepatocytes, vascular smooth muscle cells, and chondrocytes. iNOS...
| Schlagworte: | Anti-Nos2, Anti-iNOS, Anti-iNOS, Anti-Inosl, Anti-MAC-NOS, Anti-MAC-NOS, Anti-NOS type II, Anti-NOS type II,... |
| Anwendung: | IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
468,00 €
1400W (hydrochloride)
Artikelnummer: Cay81520-5
1400W is a potent, selective inhibitor of iNOS. Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively. In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS. In mice bearing a murine mammary carcinoma, continuous infusion of 1400W...
| Schlagworte: | N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride |
| Anwendung: | iNOS inhibitor |
| CAS | 214358-33-5 |
| MW: | 250.2 D |
ab 81,00 €
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
Artikelnummer: Cay81880-5
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO),...
| Schlagworte: | BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride |
| Anwendung: | NOS cofactor |
| CAS | 69056-38-8 |
| MW: | 314.2 D |
ab 60,00 €
TRIM
Artikelnummer: Cay81310-50
TRIM is an inhibitor of nNOS and iNOS. It exhibits IC50 values of 28.2 µM, 27.0 µM, and 1.06 mM for the inhibition of nNOS (mouse), iNOS (rat), and eNOS (bovine), respectively. TRIM inhibits mouse nNOS with Ki values of 47.3 and 462 µM in the absence and presence of BH4, respectively, suggesting TRIM interferes with...
| Schlagworte: | 1-(alpha,alpha,alpha-trifluoro-o-tolyl)-Imidazole, 1-[2-(trifluoromethyl)phenyl]-1H-imidazole |
| Anwendung: | iNOS inhibitor, nNOS inhibitor |
| CAS | 25371-96-4 |
| MW: | 212.2 D |
ab 50,00 €
L-NIO (hydrochloride)
Artikelnummer: Cay80320-50
L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 µM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.Formal...
| Schlagworte: | N5-(1-iminoethyl)-L-ornithine, dihydrochloride |
| Anwendung: | NOS inhibitor |
| CAS | 36889-13-1 |
| MW: | 246.1 D |
ab 26,00 €
1400W . dihydrochloride
Artikelnummer: AG-CR1-0018-M005
A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd &le, 7 nM), Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki &le, 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki &le, 50 µM), Inhibits tumor growth, Increases...
| Schlagworte: | N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl |
| Anwendung: | iNOS inhibitor |
| CAS | 214358-33-5 |
| MW: | 250,3 D |
ab 44,00 €
Aminoguanidine (hydrochloride)
Artikelnummer: Cay81530-10
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.Formal Name: hydrazinecarboximidamide,...
| Schlagworte: | Aminoguanidinium chloride, GER 11, Pimagedine, hydrazinecarboximidamide, monohydrochloride |
| Anwendung: | iNOS inhibitor |
| CAS | 1937-19-5 |
| MW: | 110.5 D |
ab 38,00 €