GW 6471

The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation. GW 6471 is an antagonist of PPARalpha (IC50 = 240 nM). It drives the displacement of coactivators from PPARalpha and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARalpha antagonism.Formal Name: N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-propanamide. CAS Number: 880635-03-0. Molecular Formula: C35H36F3N3O4. Formula Weight: 619.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 11 mg/ml, Ethanol: 10 mg/ml. lambdamax: 225, 278, 347, 352 nm. SMILES: CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[C@@H](CNC(CC)=O)N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)C=C3. InChi Code: InChI=1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1. InChi Key: TYEFSRMOUXWTDN-DYQICHDWSA-N.