Zu "K05692" wurden 147 Artikel gefunden!
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Latrunculin A Artikelnummer: Cay10010630-100
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
| Schlagworte: | NSC 613011,... |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421.6 D |
ab 49,00 €
Latrunculin B Artikelnummer: AG-CN2-0031-M001
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Less potent than Latrunculin A. May have fewer unwanted effects than latrunculin A and may be...
| Schlagworte: | LAT-B, NSC 339663 |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-94-7 |
| MW: | 395,5 D |
ab 99,00 €
Aktion
Anti-beta-Actin Artikelnummer: 600-401-886
Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [The UniProt Consortium]
| Schlagworte: | Anti-ACTB |
| Anwendung: | WB, ELISA, IF, IHC |
| Reaktivität: | Human |
421,00 €
Phalloidin Amine Artikelnummer: ABD-5302
Phalloidin, a bicyclic heptapeptide toxin, binds specifically at the interface between F-actin subunits, locking adjacent subunits together. Phalloidin binds to actin filaments much more tightly than to actin monomers, leading to a decrease in the rate constant for the dissociation of actin subunits from filament...
| Anwendung: | Actin filament stabilizer, ATP hydrolysis activity inhibitor |
| MW: | 901,91 D |
230,00 €
Latrunculin A Artikelnummer: AG-CN2-0027-C100
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Potent phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in...
| Schlagworte: | LAT-A, NSC 613011 |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421,6 D |
ab 121,00 €
Cytochalasin B Artikelnummer: Cay11328-10
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
| Schlagworte: | NSC 107658, Phomin,... |
| Anwendung: | Mycotoxin |
| CAS | 14930-96-2 |
| MW: | 479.6 D |
ab 44,00 €
Latrunculin B Artikelnummer: Cay10010631-100
The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells. Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin...
| Schlagworte: | 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-94-7 |
| MW: | 395.5 D |
ab 30,00 €
Cytochalasin D Artikelnummer: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
| Schlagworte: | NSC 209835,... |
| Anwendung: | Cell-permeable actin polymerization inhibitor |
| CAS | 22144-77-0 |
| MW: | 507.6 D |
ab 78,00 €
Jasplakinolide Artikelnummer: Cay11705-50
Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in...
| Schlagworte: | NSC 613009,... |
| Anwendung: | Actin studies |
| CAS | 102396-24-7 |
| MW: | 709.7 D |
ab 207,00 €
Cucurbitacin E Artikelnummer: AG-CN2-0474-M001
Off-white powder. Soluble in DMSO. Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site, Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin...
| Schlagworte: | Cuc E, alpha-Elaterin, alpha-Elaterine, NSC106399, BRN2343323 |
| Anwendung: | Actin depolymerization inhibitor |
| CAS | 18444-66-1 |
| MW: | 556,7 D |
ab 39,00 €
Anti-Cytoskeletal Actin Artikelnummer: A300-491A
Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [The UniProt Consortium]
| Schlagworte: | Anti-ACTB |
| Anwendung: | WB, IP, IHC |
| Reaktivität: | Human, Mouse |
ab 131,00 €
Cytochalasin A Artikelnummer: Cay11327-5
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 µM)....
| Schlagworte: | Dehydrophomin, NSC 174119, Phomin,... |
| Anwendung: | Actin polymerisation inhibitor |
| CAS | 14110-64-6 |
| MW: | 477.6 D |
ab 50,00 €