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Latrunculin A
Latrunculin A

Artikelnummer: Cay10010630-100

Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
Schlagworte: NSC 613011,...
Anwendung: Actin polymerization inhibitor
CAS 76343-93-6
MW: 421.6 D
ab 49,00 €
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Latrunculin B
Latrunculin B

Artikelnummer: AG-CN2-0031-M001

Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Less potent than Latrunculin A. May have fewer unwanted effects than latrunculin A and may be...
Schlagworte: LAT-B, NSC 339663
Anwendung: Actin polymerization inhibitor
CAS 76343-94-7
MW: 395,5 D
ab 99,00 €
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Aktion
Anti-beta-Actin
Anti-beta-Actin

Artikelnummer: 600-401-886

Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [The UniProt Consortium]
Schlagworte: Anti-ACTB
Anwendung: WB, ELISA, IF, IHC
Reaktivität: Human
421,00 €
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Phalloidin Amine
Phalloidin Amine

Artikelnummer: ABD-5302

Phalloidin, a bicyclic heptapeptide toxin, binds specifically at the interface between F-actin subunits, locking adjacent subunits together. Phalloidin binds to actin filaments much more tightly than to actin monomers, leading to a decrease in the rate constant for the dissociation of actin subunits from filament...
Anwendung: Actin filament stabilizer, ATP hydrolysis activity inhibitor
MW: 901,91 D
230,00 €
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Latrunculin A
Latrunculin A

Artikelnummer: AG-CN2-0027-C100

Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Potent phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in...
Schlagworte: LAT-A, NSC 613011
Anwendung: Actin polymerization inhibitor
CAS 76343-93-6
MW: 421,6 D
ab 121,00 €
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Cytochalasin B
Cytochalasin B

Artikelnummer: Cay11328-10

Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
Schlagworte: NSC 107658, Phomin,...
Anwendung: Mycotoxin
CAS 14930-96-2
MW: 479.6 D
ab 44,00 €
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Latrunculin B
Latrunculin B

Artikelnummer: Cay10010631-100

The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells. Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin...
Schlagworte: 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Anwendung: Actin polymerization inhibitor
CAS 76343-94-7
MW: 395.5 D
ab 30,00 €
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Cytochalasin D
Cytochalasin D

Artikelnummer: Cay11330-1

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
Schlagworte: NSC 209835,...
Anwendung: Cell-permeable actin polymerization inhibitor
CAS 22144-77-0
MW: 507.6 D
ab 78,00 €
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Jasplakinolide
Jasplakinolide

Artikelnummer: Cay11705-50

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in...
Schlagworte: NSC 613009,...
Anwendung: Actin studies
CAS 102396-24-7
MW: 709.7 D
ab 207,00 €
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Cucurbitacin E
Cucurbitacin E

Artikelnummer: AG-CN2-0474-M001

Off-white powder. Soluble in DMSO. Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site, Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin...
Schlagworte: Cuc E, alpha-Elaterin, alpha-Elaterine, NSC106399, BRN2343323
Anwendung: Actin depolymerization inhibitor
CAS 18444-66-1
MW: 556,7 D
ab 39,00 €
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Anti-Cytoskeletal Actin
Anti-Cytoskeletal Actin

Artikelnummer: A300-491A

Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [The UniProt Consortium]
Schlagworte: Anti-ACTB
Anwendung: WB, IP, IHC
Reaktivität: Human, Mouse
ab 131,00 €
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Cytochalasin A
Cytochalasin A

Artikelnummer: Cay11327-5

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 µM)....
Schlagworte: Dehydrophomin, NSC 174119, Phomin,...
Anwendung: Actin polymerisation inhibitor
CAS 14110-64-6
MW: 477.6 D
ab 50,00 €
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