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IOX2
Artikelnummer: Cay11573-10
IOX2 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 µM). IOX2 is active in cells, inhibiting HIF-1alpha hydroxylation in RCC4 cells at 50 µM. See the...
| Schlagworte: | N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine |
| Anwendung: | PHD2 inhibitor |
| CAS | 931398-72-0 |
| MW: | 352.3 D |
ab 94,00 €
IOX2
Artikelnummer: TGM-T1823-10mg
Description: IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD), active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O. References: Murray...
| Schlagworte: | IOX 2, JICL38 |
| Anwendung: | PHD2 inhibitor |
| CAS | 931398-72-0 |
| MW: | 352.34 D |
ab 34,00 €
IOX2
Artikelnummer: LKT-I5992.100
IOX2 is an inhibitor of prolyl hydroxylase that activates HIF-1 and as a result, exhibits pro-angiogenic activity.
| Anwendung: | PHD2 inhibitor |
| CAS | 931398-72-0 |
| MW: | 352.34 D |
ab 109,00 €
