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KM11060
Artikelnummer: TGM-T3135-100mg
Description: KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane. Target: CFTR, Autophagy. Smiles: Clc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12. References: Robert R, et al. Mol Pharmacol. 2008...
| Anwendung: | CFTR F508del processing correction |
| CAS | 774549-97-2 |
| MW: | 422.33 D |
ab 31,00 €
KM 11060
Artikelnummer: Cay23481-10
KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients. It increases cell surface expression and restores chloride transport function of F508del-CFTRs in...
| Schlagworte: | 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline |
| Anwendung: | CFTR F508del processing correction |
| CAS | 774549-97-2 |
| MW: | 422.3 D |
ab 124,00 €
