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OSI-930
Artikelnummer: TGM-T2624-100mg
Description: OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors. Target: Apoptosis, FLT, Raf, c-Fms, Src, CSF-1R, c-Kit, VEGFR. Smiles:...
| Schlagworte: | OSI 930 |
| Anwendung: | Kit / VEGFR2 dual inhibitor |
| CAS | 728033-96-3 |
| MW: | 443.44 D |
ab 46,00 €
OSI-930
Artikelnummer: Cay29379-10
OSI-930 is a dual inhibitor of Kit (IC50s = 80 and 629 nM for the activated and non-activated kinase, respectively, in cell-free assays) and VEGFR2 (IC50 = 9 nM). It is selective for these kinases over a panel of 17 additional kinases (IC50s = 1.3->10 µM) but also inhibits VEGFR1, CSF1R, C-RAF, and LCK (IC50s = 8,...
| Schlagworte: | 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide |
| Anwendung: | Kit / VEGFR2 dual inhibitor |
| CAS | 728033-96-3 |
| MW: | 443.4 D |
ab 150,00 €
