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PD 407824
Artikelnummer: TGM-T16446-1mg
Description: PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively). Target: Chk, Wee1. Smiles: Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1....
| Schlagworte: | PD-407824 |
| Anwendung: | Chk1 / WEE1 inhibitor |
| CAS | 622864-54-4 |
| MW: | 328.32 D |
69,00 €
PD 407824
Artikelnummer: Cay25989-1
PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM), Cdk4 (IC50 = 3.75 µM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other Cdks (IC50s = >50 µM). PD 407824 sensitizes...
| Schlagworte: | 9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Anwendung: | Chk1 / WEE1 inhibitor |
| CAS | 622864-54-4 |
| MW: | 328.3 D |
ab 67,00 €
