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INCB086550
Artikelnummer: TGM-T36899-100mg
Description: INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. Target: PD-1/PD-L1. Smiles: Cc1c(Nc2nccc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C. References: WU LIANGXING, et al. BENZOOXAZOLE DERIVATIVE SASIMMUNOMODULATORS....
| Schlagworte: | PD-1/PD-L1-IN-8 |
| Anwendung: | PD-1/PD-L1 interaction inhibitor |
| CAS | 2230911-59-6 |
| MW: | 693.79 D |
ab 147,00 €
INCB 086550
Artikelnummer: Cay38781-1
INCB 086550 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. It inhibits PD-1 binding to PD-L1 in CHO cells expressing human PD-L1 (EC50 = 13.2 nM). INCB 086550 (1 µM) induces dimerization and internalization of PD-L1 in CHO cells expressing human PD-L1....
| Schlagworte: | (3R)-1-[[7-cyano-2-[3'-[[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-1,7-naphthyridin-8-yl]amino]-2,2'-dimethyl[1,1'-bipheny... |
| Anwendung: | PD-1/PD-L1 interaction inhibitor |
| CAS | 2230911-59-6 |
| MW: | 693.8 D |
ab 78,00 €
